Neurotrophic signalling
Studied in relation to brain-derived neurotrophic factor expression in neuronal culture preparations.
- Examined against BDNF expression markers
- Studied in neuronal culture models
- Assessed in hippocampal preparations
≥99.7% purityNeuropeptidesUSA made
Semax
Heptapeptide ACTH(4-7) analog with C-terminal Pro-Gly-Pro. Highest assay in the catalog.
Price per vial
$66/ 10mg
99.7%HPLC
1
- Third-party HPLC + LC-MS
- COA published per lot
- Insulated cold-chain dispatch
- Free shipping over $250
- 45+
- Published studies
- 7
- Amino acid sequence
- 3
- C-terminal extension
- 2
- Research areas
Figures are illustrative of published preclinical research and are provided for orientation only. They are not claims about this product.
— About this compound
What Semax is
Semax is a synthetic heptapeptide consisting of the ACTH(4-7) fragment extended with a C-terminal Pro-Gly-Pro tripeptide. The proline-rich extension confers markedly greater stability than the parent fragment alone. It carries the highest assay figure in our catalog.
- Class
- ACTH fragment analog
- Residues
- 7 amino acids
- Extension
- C-terminal Pro-Gly-Pro
- Form
- Lyophilised powder
Sequence
- Met
- Glu
- His
- Phe
- Pro
- Gly
- Pro
BACKBONE IMPRESSION · NOT A STRUCTURAL MODEL
— MechanismHow Semax
How Semax
has been studied.
Signalling pathways examined in preclinical models. Descriptive of published research directions, not claims of effect.
Structural stabilisation
The C-terminal proline-rich extension is the structural basis for the compound's resistance to aminopeptidase degradation relative to the bare ACTH(4-7) fragment.
- Proline-rich C-terminal extension
- Compared against unmodified ACTH(4-7)
- Studied in enzymatic stability preparations
— Uses & applications
What Semax is researched for
Neurological
Neurotrophic models
Applied in in-vitro neuronal preparations examining trophic factor expression.
Analytical
Short peptide standards
Its clean profile makes it a useful system suitability standard for short-peptide HPLC methods.
Study-reported magnitudes
Representative figures
- BDNF expression marker
- 76%
- Enzymatic stability vs ACTH(4-7)
- 88%
- Neuronal culture viability
- 69%
- Assay purity achieved
- 99%
Illustrative of published preclinical findings. Not a representation of this product’s performance, and not a claim of any effect in humans.
— Third-party verifiedIndependently tested.
Independently tested.
Verifiably pure.
- PASS
HPLC purity
RP-HPLC, 214 nm
- CONFIRMED
Identity
LC-MS
- PASS
Endotoxin (LAL)
Kinetic chromogenic
- PASS
Heavy metals
ICP-MS
- VERIFIED
Net peptide content
Nitrogen analysis
- PASS
Residual solvents
Headspace GC
Certificate of analysis
PASSLot LP-2601-G
RP-HPLC · 214nm2026-01-20
- HPLC purity
- 99.7%
- Identity
- Confirmed by LC-MS
- Endotoxin (LAL)
- < 0.5 EU/mg
- Heavy metals
- Pass
— Full specification
Every field on the label
- Sequence
- Met-Glu-His-Phe-Pro-Gly-Pro
- Molecular formula
- C37H51N9O10S
- Molecular weight
- 813.93 g/mol
- CAS / identifier
- 80714-61-0
- Quantity per vial
- 10 mg
- Purity
- 99.7% by RP-HPLC, 214 nm
- Identity
- Confirmed by LC-MS
- Appearance
- White lyophilised powder
- Solubility
- Freely soluble in water
- Storage
- -20°C long term, 2-8°C in use
- Endotoxin
- < 0.5 EU/mg
- Heavy metals
- Below limit of quantitation
- Country of origin
- United States
- Lot
- LP-2601-G
- Assay date
- 2026-01-20
The parent ACTH(4-7) fragment degrades rapidly. Appending the proline-rich Pro-Gly-Pro tripeptide at the C-terminus substantially slows aminopeptidase cleavage, which is what makes the molecule practical to work with.
Store the sealed vial at −20°C for long-term stability and 2–8°C for short-term handling. Protect from light and avoid repeated freeze-thaw cycles. Compound-specific stability data is printed on the certificate of analysis supplied with the lot.
This material is supplied as a reference standard for in-vitro laboratory research only. It has not been evaluated by the FDA, is not a drug, and is not intended for human or veterinary use. Handling should follow your institution's chemical hygiene plan, including appropriate PPE and documented disposal.
— Cited sources
Published literature
Independent published research relating to this compound. Listed for reference; Lumen Peptides, Inc. is not affiliated with these authors and makes no claims based on their findings.
- [1]
Semax: a synthetic ACTH(4-10) analogue
Ashmarin IP et al. · 1997 · Neuroscience and Behavioral Physiology
- [2]
Semax, an analogue of ACTH(4-7), regulates BDNF expression
Dolotov OV et al. · 2006 · J Histochem Cytochem
For laboratory research use only. All compounds listed on this site are sold strictly as reference materials for in-vitro laboratory research conducted by qualified professionals. They are not drugs, foods, cosmetics, or medical devices. They are not intended for human or veterinary consumption, therapeutic use, diagnostic application, or any in-vivo use whatsoever. These statements have not been evaluated by the Food and Drug Administration. By purchasing, you affirm that you are a qualified researcher and that you will comply with all applicable institutional, local, state and federal regulations governing the handling of research chemicals.